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Article Dans Une Revue Molecular Cell Année : 2024

Sister chromatid cohesion halts DNA loop expansion

Résumé

Eukaryotic genomes are folded into DNA loops mediated by structural maintenance of chromosomes (SMC) complexes such as cohesin, condensin, and Smc5/6. This organization regulates different DNA-related processes along the cell cycle, such as transcription, recombination, segregation, and DNA repair. During the G2 stage, SMC-mediated DNA loops coexist with cohesin complexes involved in sister chromatid cohesion (SCC). However, the articulation between the establishment of SCC and the formation of SMC-mediated DNA loops along the chromatin remains unknown. Here, we show that SCC is indeed a barrier to cohesin-mediated DNA loop expansion along G2/M Saccharomyces cerevisiae chromosomes.

Domaines

Génétique

Dates et versions

pasteur-04603601 , version 1 (06-06-2024)

Identifiants

Citer

Nathalie Bastié, Christophe Chapard, Axel Cournac, Sanae Nejmi, Henri Mboumba, et al.. Sister chromatid cohesion halts DNA loop expansion. Molecular Cell, 2024, 84 (6), pp.1139-1148.e5. ⟨10.1016/j.molcel.2024.02.004⟩. ⟨pasteur-04603601⟩
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