Article Dans Une Revue Chemistry - A European Journal Année : 2025

Photoresponsive Helical Foldamers: Conformational Control through Double Helix Formation and Light‐Induced Protonation

Louis Hardoin
  • Fonction : Auteur
Rana Kdouh
  • Fonction : Auteur
Youssef Aidibi
  • Fonction : Auteur
Soussana Azar
  • Fonction : Auteur
Benjamin Siegler
  • Fonction : Auteur
Magali Allain
Sébastien Goeb
Eric Levillain
Marc Sallé
David Canevet
  • Fonction : Auteur correspondant

Résumé

Helical foldamers constitute particularly relevant targets in the field of host‐guest chemistry, be that as hosts or substrates. In this context, the strategies reported so far to control the dimensions and shape of foldamers mainly involve modifications of the skeleton through covalent synthesis. Herein, we prepared an oligopyridine dicarboxamide foldamer substituted by photo‐active tetraphenylethylenes (TPE). We demonstrate that it is possible to toggle the length of a helical foldamer by two means. First, the elongation of foldamers can be tuned by adjusting the concentration, as demonstrated by DOSY NMR spectroscopy and X‐ray diffraction analyses on both the single and the double helix structures. Secondly, and in a more original manner, a photo‐induced protonation process triggered by TPE units promotes a novel pathway to unfold helical foldamers, leading to dramatic conformational and spectroscopic changes.
Fichier principal
Vignette du fichier
Chemistry A European J - 2025 - Hardoin - Photoresponsive Helical Foldamers Conformational Control Through Double Helix-2.pdf (1) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-04865337 , version 1 (24-02-2025)

Licence

Identifiants

Citer

Louis Hardoin, Rana Kdouh, Youssef Aidibi, Soussana Azar, Benjamin Siegler, et al.. Photoresponsive Helical Foldamers: Conformational Control through Double Helix Formation and Light‐Induced Protonation. Chemistry - A European Journal, 2025, 31 (11), pp.e202403771. ⟨10.1002/chem.202403771⟩. ⟨hal-04865337⟩
13 Consultations
0 Téléchargements

Altmetric

Partager

More