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Article Dans Une Revue (Article De Synthèse) Journal of Molecular Biology Année : 2017

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

Résumé

For decades, it has been speculated that specific loci on eukaryotic chromosomes are inherently susceptible to breakage. The advent of high-throughput genomic technologies has now paved the way to their identification. A wealth of data suggests that transcriptionally active loci are particularly fragile and that a specific DNA damage response is activated and dedicated to their repair. Here, we review current understanding of the crosstalk between transcription and double-strand break repair, from the reasons underlying the intrinsic fragility of genes to the mechanisms that restore the integrity of damaged transcription units.
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hal-04121153 , version 1 (07-06-2023)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Aline Marnef, Sarah Cohen, Gaëlle Legube. Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care. Journal of Molecular Biology, 2017, 429 (9), pp.1277-1288. ⟨10.1016/j.jmb.2017.03.024⟩. ⟨hal-04121153⟩
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