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Pré-Publication, Document De Travail (Preprint/Prepublication) Année : 2022

Optimal feedback control strategies in a generic class of bacterial growth models with multiple substrates

Résumé

Optimal control strategies are studied through the application of the Pontryagin's Maximum Principle for a class of non-linear differential systems that are commonly used to describe resource allocation during bacterial growth. The approach is inspired by the optimality of numerous regulatory mechanisms in bacterial cells. In this context, we aim to predict natural feedback loops as optimal control solutions so as to gain insight on the behavior of microorganisms from a control-theoretical perspective. The problem is posed in terms of a control function modeling the resources assigned to two main cellular functions, and n additional controls responsible for the consumption of the available nutrient sources in the medium. By studying the necessary conditions for optimality, it is possible to prove that the solutions follow a bang-singular-bang structure, and that---under certain conditions---they can be expressed in feedback form. The optimal solutions are characterized by a sequential uptake pattern known as diauxic growth, which prioritizes the consumption of richer substrates over poor nutrients. Numerical simulations obtained through an optimal control solver confirm the theoretical results. Additionally, we provide an application to batch cultivation of E. coli growing on glucose and lactose by calibrating the obtained closed-loop model to experimental data.
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Dates et versions

hal-03913957 , version 1 (27-12-2022)
hal-03913957 , version 2 (17-10-2023)

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  • HAL Id : hal-03913957 , version 1

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Agustín Gabriel Yabo. Optimal feedback control strategies in a generic class of bacterial growth models with multiple substrates. 2022. ⟨hal-03913957v1⟩
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