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Article Dans Une Revue Crystal Growth & Design Année : 2016

Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis

Résumé

We have investigated the amorphization of β-trehalose by high energy milling using in situ and ex situ synchrotron powder diffraction and PDF analysis. From this analysis we show that amorphization takes place through a two-phase process involving an amorphous and a long-range ordered phase. The proportion and coherent domain size of the latter rapidly decrease with milling time until the whole sample appears amorphized. The PDF describing the local structure of the amorphous phase after two hours of milling is very close to that of a sample quenched from the liquid, and seems to continue to evolve for longer milling times. Their differences with the PDF expected for a rigid THL molecule confirm the existence of a conformational disorder of the torsion angles from the glycosidic linkage between the two cycles forming the molecule.
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Dates et versions

hal-01355791 , version 1 (24-08-2016)

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Pierre Bordet, Aleksei Bytchkov, Marc Descamps, Emeline Dudognon, Erik Elkaïm, et al.. Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis. Crystal Growth & Design, 2016, 16 (8), pp.4547-4558. ⟨10.1021/acs.cgd.6b00660⟩. ⟨hal-01355791⟩
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