Nigrostriatal dopaminergic denervation does not promote impulsive choice in the rat: tmplication for impulse control disorders in Parkinson’s disease - Grenoble Institut Neurociences
Article Dans Une Revue Frontiers in Behavioral Neuroscience Année : 2018

Nigrostriatal dopaminergic denervation does not promote impulsive choice in the rat: tmplication for impulse control disorders in Parkinson’s disease

Résumé

Impulse control disorders (ICDs) are frequent behavioral complications of dopaminergic (DA) replacement therapies (DRTs) in Parkinson's disease (PD). Impulsive choice, which refers to an inability to tolerate delays to reinforcement, has been identified as a core pathophysiological process of ICDs. Although impulsive choices are exacerbated in PD patients with ICDs under DRTs, some clinical and preclinical studies suggest that the DA denervation of the dorsal striatum induced by the neurodegenerative process as well as a pre-existing high impulsivity trait, may both contribute to the emergence of ICDs in PD. We therefore investigated in a preclinical model in rats, specifically designed to study PD-related non-motor symptoms, the effect of nigrostriatal DA denervation on impulsive choice, in relation to pre-existing levels of impulsivity, measured in a Delay Discounting Task (DDT). In this procedure, rats had the choice between responding for a small sucrose reinforcer delivered immediately, or a larger sucrose reinforcer, delivered after a 0, 5, 10 or 15 s delay. In two different versions of the task, the preference for the large reinforcer decreased as the delay increased. However, and in contrast to our initial hypothesis, this discounting effect was neither exacerbated by, or related to, the extent of the substantia nigra pars compacta (SNc) DA lesion, nor it was influenced by pre-existing variability in impulsive choice. These results therefore question the potential implication of the nigrostriatal DA system in impulsive choice, as well as the DA neurodegenerative process as a factor contributing significantly to the development of ICDs in PD.
Fichier principal
Vignette du fichier
fnbeh-12-00312.pdf (1.7 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-04707290 , version 1 (07-01-2025)

Identifiants

Citer

Robin Magnard, Yvan Vachez, Carole Carcenac, Sabrina Boulet, Jean Luc Houeto, et al.. Nigrostriatal dopaminergic denervation does not promote impulsive choice in the rat: tmplication for impulse control disorders in Parkinson’s disease. Frontiers in Behavioral Neuroscience, 2018, 12, pp.312. ⟨10.3389/fnbeh.2018.00312⟩. ⟨hal-04707290⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

More